| 產(chǎn)品編號(hào) | bs-19225R-Cy3 |
| 英文名稱1 | Rabbit Anti-NFKBIL2/Cy3 Conjugated antibody |
| 中文名稱 | Cy3標(biāo)記的核因子κB抑制蛋白樣蛋白2抗體 |
| 別 名 | I kappa B related protein; I-kappa-B-related protein; IkappaBR; IKBR; Inhibitor of kappa B related protein; Inhibitor of kappa B-related protein; MMS22L-interacting protein; MMS22L-interacting protein, NFBIL2/TONSL; NF kappa B inhibitor like protein 2; NF-kappa-B inhibitor-like protein 2; NFBIL2; NFBIL2/TONSL; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; Protein IkappaBR; Tonsl; TONSL_HUMAN; Tonsoku-like protein; tonsoku-like, DNA repair protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Mouse, Rat, Dog, Horse, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 175kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NFKBIL2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] Function: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. Subcellular Location: Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Tissue Specificity: Expressed in heart, skeletal muscle and tracheal epithelial cells. Similarity: Belongs to the Tonsoku family. Contains 3 ANK repeats. Contains 7 LRR (leucine-rich) repeats. Contains 8 TPR repeats. Database links: Entrez Gene: 4796 Human Entrez Gene: 72749 Mouse Omim: 604546 Human SwissProt: Q96HA7 Human SwissProt: Q6NZL6 Mouse Unigene: 675285 Human Unigene: 358749 Mouse Unigene: 19092 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
