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Rabbit Anti-NFRKB/PE-Cy3 Conjugated antibody (bs-19226R-PE-Cy3)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19226R-PE-Cy3
英文名稱1 Rabbit Anti-NFRKB/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的DNA結(jié)合蛋白κB抗體
別    名 A530090G11Rik; DKFZp547B2013; DNA binding protein R kappa B; INO80 complex subunit G; INO80G; Nuclear factor related to kappa B binding protein; Nuclear factor related to kappaB binding protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NFRKB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
DNA-binding protein R kappa-B, is a nuclear protein that binds to the DNA consensus sequence 5'-GGGGAATCTCC-3' of NF kappa B. Binding of NFR kappa B is thought to regulate IL-2R alpha (interleukin-2 receptor alpha-chain) gene expression, a critical step in T-cell activation. NFR kappa B exists as 3 isoforms due to alternative splicing and is expressed primarily in the brain, liver, spleen, testis and thymus NFR kappa B gene expression is amplified in acute myeloid leukemia, suggesting a possible role in carcinogenesis.

Function:
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in thymus, brain, testes, spleen and liver.

Database links:

Entrez Gene: 419727 Chicken

Entrez Gene: 419730 Chicken

Entrez Gene: 4798 Human

Entrez Gene: 235134 Mouse

Entrez Gene: 315523 Rat

Omim: 164013 Human

SwissProt: Q6P4R8 Human

SwissProt: Q6PIJ4 Mouse

Unigene: 530539 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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