| 產(chǎn)品編號(hào) | bs-13698R-Gold |
| 英文名稱1 | Rabbit Anti-RAGEF2/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的RAGEF2蛋白抗體 |
| 別 名 | DKFZp667N084; DKFZp686I15116; KIA001LB; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain containing guanine nucleotide exchange factor 2; PDZ domain containing guanine nucleotide exchange factor I; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ GEF 2; PDZ GEF2; PDZ-GEF2; PDZGEF 2; PDZGEF2; RA GEF 2; RA GEF2; RA-GEF-2; RAGEF 2; Rap guanine nucleotide exchange factor (GEF) 6; Rap guanine nucleotide exchange factor 2; Rap guanine nucleotide exchange factor 6; RAPGEF6; RPGF6_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白信號(hào) 跨膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 179kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAGEF2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B. Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. Subcellular Location: Cytoplasm. Cell membrane. Upon binding to M-Ras, it translocates to the plasma membrane. Tissue Specificity: Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 cyclic nucleotide-binding domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PDZ (DHR) domain. Contains 1 Ras-associating domain. Contains 1 Ras-GEF domain. Database links: Entrez Gene: 51735 Human Omim: 610499 Human SwissProt: Q8TEU7 Human Unigene: 483329 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
