| 產(chǎn)品編號(hào) | bs-13255R-APC |
| 英文名稱1 | Rabbit Anti-GAB3/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的生長(zhǎng)因子受體結(jié)合蛋白2相關(guān)蛋白3抗體 |
| 別 名 | Gab3; GAB3_HUMAN; GRB2-associated binder 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 生長(zhǎng)因子和激素 細(xì)胞分化 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GAB3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5). Subunit: Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2. Post-translational modifications: Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation. Similarity: Belongs to the GAB family. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q8WWW8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
