| 產(chǎn)品編號 | bs-1290R-BF488 |
| 英文名稱1 | Rabbit Anti-CCN1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的富半胱氨酸肝素結(jié)合蛋白61抗體 |
| 別 名 | Cyr61; IGFBP10; cysteine rich protein 61; 3CH61; CCN 1; CCN1; CYR 61; CYR61; CYR61 protein; CYR61 protein precursor; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; GIG 1; GIG1; GIG1; Igfbp 10; IGFBP10; Insulin like growth factor binding protein 10; Protein CYR61; Protein GIG1; AI325051; cysteine rich 61; CYR61_HUMAN . |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cyr61 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Subcellular Location: Secreted. Similarity: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain. Database links: Entrez Gene: 3491 Human Entrez Gene: 16007 Mouse Omim: 602369 Human SwissProt: O00622 Human SwissProt: P18406 Mouse Unigene: 8867 Human Unigene: 1231 Mouse Unigene: 22129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 高半胱氨酸蛋白61是富含半胱氨酸的分泌性肝素連接蛋白，是CCN家族成員之一，屬于生長因子誘導(dǎo)的即刻早期基因，有明顯的促有絲分裂和趨化活性作用，有誘導(dǎo)成纖維細(xì)胞增殖和分泌細(xì)胞外基質(zhì)等功能，可促進細(xì)胞增殖、遷移、黏附、分化和細(xì)胞外基質(zhì)（ECM）合成的作用，在新生血管及腫瘤形成過程中起著重要作用。 |
