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Rabbit Anti-Ribonuclease 6/PE-Cy3 Conjugated antibody (bs-5972R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5972R-PE-Cy3
英文名稱1 Rabbit Anti-Ribonuclease 6/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的核糖核酸酶6抗體
別    名 Ribonuclease T2; RNASE6PL; RP11 514O12.3; RNASET2; RNASE6PL; RNT2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞凋亡  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RelB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. There are 2 isoforms produced by alternative splicing.

Subcellular Location:
Secreted. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

Tissue Specificity:
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.

DISEASE:
Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

Similarity:
Belongs to the RNase T2 family.

Database links:

Entrez Gene: 8635 Human

Entrez Gene: 100037283 Mouse

Entrez Gene: 68195 Mouse

Entrez Gene: 292306 Rat

Omim: 612944 Human

SwissProt: O00584 Human

SwissProt: Q9CQ01 Mouse

Unigene: 529989 Human

Unigene: 181237 Mouse

Unigene: 426736 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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