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Rabbit Anti-E2F8/Gold Conjugated antibody (bs-4265R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-4265R-Gold
英文名稱1 Rabbit Anti-E2F8/Gold Conjugated antibody
中文名稱 膠體金標記的轉錄因子E2F8抗體
別    名 E2F 8; E2F family member 82; E2F transcription factor 8; E2F-8; E2f8; E2F8_HUMAN; FLJ23311; Transcription factor E2F8.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  免疫學  染色質和核信號  信號轉導  轉錄調節(jié)因子  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Pig, Horse, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human E2F8 (285-326aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].

Function:
Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.

Subunit:
Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the E2F/DP family

Database links:

Entrez Gene: 79733 Human

Entrez Gene: 108961 Mouse

Entrez Gene: 308607 Rat

Omim: 612047 Human

SwissProt: A0AVK6 Human

SwissProt: Q58FA4 Mouse

Unigene: 523526 Human

Unigene: 240566 Mouse

Unigene: 395068 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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