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Rabbit Anti-phospho-PTK2 (Tyr576+Tyr577)/BF555 Conjugated antibody (bs-5541R-BF555)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5541R-BF555
英文名稱1 Rabbit Anti-phospho-PTK2 (Tyr576+Tyr577)/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的磷酸化粘著斑激酶抗體
別    名 PTK2 (phospho Y576/Y577); FAK (phospho Y576 + Y577); FADK 1; FADK; FAK related non kinase polypeptide; FAK1; FAK1_HUMAN; Focal adhesion kinase 1; Focal adhesion Kinase; Focal adhesion kinase isoform FAK Del33; Focal adhesion kinase related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; Protein tyrosine kinase 2; Protein-tyrosine kinase 2; Ptk2; PTK2 protein tyrosine kinase 2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 116kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PTK2 around the phosphorylation site of Tyr576+Tyr577
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.

Subcellular Location:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Nucleus.

Tissue Specificity:
Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5747 Human

Entrez Gene: 14083 Mouse

Entrez Gene: 25614 Rat

Omim: 600758 Human

SwissProt: Q05397 Human

SwissProt: P34152 Mouse

SwissProt: O35346 Rat

Unigene: 395482 Human

Unigene: 254494 Mouse

Unigene: 2809 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

????FAK是整合蛋白介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)中的重要成員,有酪氨酸蛋白激酶活性,并可自身磷酸化,FAK本身是胱冬肽酶(caspase)的底物。作為信號(hào)分子的FAK參與抑制細(xì)胞凋亡并直接參與細(xì)胞多種功能的調(diào)節(jié)。
????1.FAK 局部粘著斑激酶,是一種酪氨酸激酶;腫瘤細(xì)胞的侵襲性生長(zhǎng)是一個(gè)多步驟的復(fù)雜過(guò)程,有多種生物化學(xué)因子參與其中,局部粘著斑激酶(focal adhesion kinase, FAK)介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)系統(tǒng)就是其中最為重要的細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)途徑之一。腫瘤細(xì)胞必須黏附于細(xì)胞外基質(zhì),通過(guò)促進(jìn)依賴于PTK激酶活性的細(xì)胞外基質(zhì)信號(hào)轉(zhuǎn)導(dǎo),進(jìn)而影響細(xì)胞的黏附、運(yùn)動(dòng)與遷移。
????2.粘著斑激酶(focal adhesion kinase,FAK)是整合蛋白介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)中的重要成員,有酪氨酸蛋白激酶活性,并可自身磷酸化;為信號(hào)分子的FAK,還與細(xì)胞內(nèi)其他信號(hào)轉(zhuǎn)導(dǎo)通路存在串話(crosstalk),直接參與了細(xì)胞多種功能的調(diào)節(jié)。
????3.盡管FAK的確切功能尚不清楚,但若干實(shí)驗(yàn)均提示FAK可能有兩個(gè)作用,一是在細(xì)胞鋪展和移動(dòng)時(shí),FAK參與粘著斑形成和調(diào)節(jié);二是FAK參與信號(hào)轉(zhuǎn)導(dǎo)過(guò)程,以告知細(xì)胞核其細(xì)胞已錨定了。近年有關(guān)FAK在細(xì)胞凋亡中的作用也業(yè)已肯定。
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