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Rabbit Anti-CCNDBP1/PE Conjugated antibody (bs-7885R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7885R-PE
英文名稱1 Rabbit Anti-CCNDBP1/PE Conjugated antibody
中文名稱 PE標記的周期素D結合蛋白1抗體
別    名 Maternal inhibition of differentiation; SECC 8; SSEC 8; CCDB1_HUMAN; CCNDBP 1; Ccndbp1; Cyclin D type binding protein 1; Cyclin-D1-binding protein 1; D type cyclin interacting protein 1; DIP 1; DIP1; GCIP; Grap 2 and cyclin D interacting protein; Grap 2 cyclin D interacting protein GCIP; Grap 2 cyclin interacting protein; Grap2 and cyclin D interacting protein; Grap2 and cyclin-D-interacting protein; Grap2 cyclin D interacting protein GCIP; Grap2 cyclin interacting protein; HHM protein; Human homolog of Maid; MAID; MAID protein; Stage specific embryonic cDNA 8.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCNDBP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

Function:
May negatively regulate cell cycle progression. May actat least in part via inhibition of the cyclin-D1/CDK4 complex,thereby preventing phosphorylation of RB1 and blockingE2F-dependent transcription.

Subunit:
Interacts with CCND1 and GRAP2. May also interact withCOPS5, RPLP0, SIRT6, SYF2 and TCF3.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Ubiquitously expressed. Expression isdown-regulated in a variety of tumor types including breast, colon,prostate and rectal tumors, and is up-regulated in certain hepaticcarcinomas.

Post-translational modifications:
Phosphorylated.

Similarity:
Belongs to the CCNDBP1 family.

Database links:
UniProtKB/Swiss-Prot: O95273.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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