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Rabbit Anti-BS69/HRP Conjugated antibody (bs-7697R-HRP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7697R-HRP
英文名稱1 Rabbit Anti-BS69/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的腺病毒5結合蛋白BS69/骨形態(tài)發(fā)生蛋白受體相關分子1抗體
別    名 Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  轉錄調節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Sheep, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A binding protein (535-584aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.

Subunit:
Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.

Subcellular Location:
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated, leading to proteasomal degradation.

Similarity:
Contains 1 bromo domain.
Contains 1 MYND-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.

Database links:

Entrez Gene: 10771 Human

Entrez Gene: 66505 Mouse

Entrez Gene: 291259 Rat

GenBank: NP_006615 Human

GenBank: NP_997644 Human

Omim: 608668 Human

SwissProt: Q15326 Human

SwissProt: Q8R5C8 Mouse

Unigene: 292265 Human

Unigene: 397307 Mouse

Unigene: 38301 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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