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Rabbit Anti-HAI-1/PE-Cy3 Conjugated antibody (bs-0540R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0540R-PE-Cy3
英文名稱1 Rabbit Anti-HAI-1/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的肝細胞生長因子激活物抑制劑/HGFA Inhibitor 1抗體
別    名 Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學  激酶和磷酸酶  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HAI-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.

Function:
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

Subunit:
Interacts with HGFAC.

Subcellular Location:
Secreted.

Similarity:
Contains 2 BPTI/Kunitz inhibitor domains.
Contains 1 LDL-receptor class A domain.
Contains 1 MANSC domain.

Database links:

Entrez Gene: 6692 Human

Omim: 605123 Human

SwissProt: O43278 Human

Unigene: 233950 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HAI-1 是一種含兩個 Kunitz 域的跨膜蛋白,可抑制由細胞膜分泌的并且以游離形式存在的 HGFA 。 HAI-1 也可以作用于其它絲氨酸蛋白酶.
HAI-1 主要在胎盤、腎、胰腺、前列腺和小腸,也有報道稱 HAI-1 會在肝癌中表達。
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