| 產(chǎn)品編號 | bs-1235R-APC |
| 英文名稱1 | Rabbit Anti-Hyaluronidase-1/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的透明質(zhì)酸酶/玻璃酸酶抗體 |
| 別 名 | HYA1; HYAL PH-20; HYAL PH20; HYAL1; HYAL3; HYAL5; Haase; Hyaluronidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; Hyaluronidase PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; SPAM1;Sperm adhesion molecule 1; Sperm surface protein PH-20; Sperm surface protein PH20; zona pellucida binding. LUCA-3; HYAL1_HUMAN; HYAL 1; Hyal-1; HYAL1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; LUCA1; Lung carcinoma protein 1; MGC45987; NAT6; Plasma hyaluronidase; Tumor suppressor LUCA 1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat Haase |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Hyaluronidase degrades hyaluronic acid, which is an important structural proteoglycan found in basement membranes and also extracellular matrices. There are six members of the hyaluronidase family. Hyaluronidase PH20 is a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane and plays a role in sperm penetration through the the hyaluronic acid-rich cumulus cell layer surrounding the oocyte. Abnormal expression of this gene has been implicated in degradation of basement membranes leading to tumor invasion and metastasis. Function: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Subcellular Location: Secreted. Lysosome. Tissue Specificity: Highly expressed in liver, kidney, lung and skin. Similarity: Belongs to the glycosyl hydrolase 56 family. Contains 1 EGF-like domain. Database links: Entrez Gene: 3373 Human Entrez Gene: 15586 Mouse Omim: 607071 Human SwissProt: Q12794 Human SwissProt: Q91ZJ9 Mouse Unigene: 75619 Human Unigene: 10305 Mouse Unigene: 475658 Mouse Unigene: 124438 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HAase是一種具有高度底物特異性的蛋白酶，使透明質(zhì)酸產(chǎn)生低分子化作用的酶之總稱,可以特異地作用于透明質(zhì)酸，通過裂解葡萄糖胺和葡萄糖醛酸的分子鍵而將透明質(zhì)酸分解為二糖成分，引起透明質(zhì)酸的解聚和降解，透明質(zhì)酸分子從膠原細(xì)纖維間隙中釋放出來并重新分布，主要定位于細(xì)胞外基質(zhì)影響細(xì)胞的增殖、分化及遷移,并在胚胎發(fā)育和腫瘤發(fā)生發(fā)展過程中發(fā)揮作用,因而它在胚胎發(fā)育、血管形成、免疫監(jiān)視以及腫瘤發(fā)生發(fā)展過程中起著重要作用。 |
