| 產(chǎn)品編號(hào) | bs-2996R-BF594 |
| 英文名稱1 | Rabbit Anti-CACNB2/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的L-型電壓依賴型鈣通道β抗體 |
| 別 名 | Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L Beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit; CACB2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CACNB2 (621-670aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Subcellular Location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Similarity: Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. Database links: Entrez Gene: 783 Human Entrez Gene: 12296 Mouse Omim: 600003 Human SwissProt: Q08289 Human SwissProt: Q8CC27 Mouse Unigene: 59093 Human Unigene: 313930 Mouse Unigene: 10739 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 電壓依賴性鈣通道(VDCC)是生物體內(nèi)一大類鈣通道蛋白,隨著膜電位的改變而出現(xiàn)通道的開放、關(guān)閉和失活,調(diào)節(jié)細(xì)胞內(nèi)Ca2+濃度,最終產(chǎn)生生物學(xué)效應(yīng).其亞型結(jié)構(gòu)各異,VDCC β亞基具有調(diào)節(jié)其通道活性的作用,VDCC存在的普遍性決定了其作用的廣泛性.在胰腺、心、腦、腎上腺、視網(wǎng)膜及神經(jīng)等組織器官均有不同程度的分布. |
