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Rabbit Anti-Chromogranin A/Biotin Conjugated antibody (bs-0539R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0539R-Bio
英文名稱1 Rabbit Anti-Chromogranin A/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的嗜鉻粒素A抗體
別    名 beta Granin; CGA; CHG A; CHGA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin; ER-37; CMGA_HUMAN.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CGA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008].

Function:
Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit:
Interacts with SCG3.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.

Post-translational modifications:
Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the chromogranin/secretogranin proteinfamily.

Database links:

Entrez Gene: 1113 Human

Entrez Gene: 12652 Mouse

Omim: 118910 Human

SwissProt: P10645 Human

SwissProt: P26339 Mouse

Unigene: 150793 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

嗜鉻粒素A蛋白存在與很多組織中:胃腸道內(nèi)分泌細(xì)胞和類癌、甲狀旁腺、垂體前葉、腎上腺髓質(zhì)、神經(jīng)節(jié)、副神經(jīng)節(jié)、胰島、甲狀腺C細(xì)胞等組織和其來源的腫瘤都表達(dá)該成分.嗜鉻素A(CgA)屬于可溶性的酸性蛋白,主要存在于神經(jīng)內(nèi)分泌細(xì)胞的分泌顆粒中,也存在于含有分泌顆粒的內(nèi)分泌細(xì)胞和神經(jīng)內(nèi)分泌細(xì)胞來源的腫瘤細(xì)胞中。檢測循環(huán)中的免疫反應(yīng)CgA對神經(jīng)內(nèi)分泌瘤具有診斷意義。另外,CgA的免疫組織化學(xué)檢測對鑒定來源于神經(jīng)內(nèi)分泌的腫瘤起到輔助作用。
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