| 產(chǎn)品編號(hào) | bs-8677R-Gold |
| 英文名稱1 | Rabbit Anti-DRIP5/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的多巴胺受體相互作用蛋白5抗體 |
| 別 名 | Dopamine receptor interacting protein 5; Dopamine receptor-interacting protein 5; DRIP 5; DRIP5; hRap1; MGC105533; RAP 1; RAP1 homolog; RAP1, yeast, homolog of antibody Repressor/activator protein 1 homolog antibody TE2IP_HUMAN; Telomeric Repeat Binding Factor 2 Interacting Protein; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting protein; TERF2-interacting telomeric protein 1; TERF2IP; TRF2 Interacting Telomeric Protein RAP1; TRF2 interacting telomeric RAP1 protein; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號(hào) 神經(jīng)生物學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010] Function: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Subcellular Location: Cytoplasm. Nucleus. Chromosome > telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. Tissue Specificity: Ubiquitous. Highly expressed. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the RAP1 family. Contains 1 BRCT domain. Contains 1 Myb-like domain. Database links: Entrez Gene: 54386 Human Omim: 605061 Human SwissProt: Q9NYB0 Human Unigene: 301419 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
