| 產(chǎn)品編號 | bs-1846R-Gold |
| 英文名稱1 | Rabbit Anti-LRIG3/Gold Conjugated antibody |
| 中文名稱 | 膠體金標記的LRIG3抗體 |
| 別 名 | leucine rich repeats and immunoglobulin-like domains 3; LIG3; LRIG1-3; LRIG3_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 細胞生物 信號轉(zhuǎn)導 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRIG3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: LRIG3 is predicted to be a 1117 amino acid single pass transmembrane protein with 15 leucine rich repeats and 3 Ig domains in the extracellular region, and a short, novel cytoplasmic tail with no known motifs. It is believed that LRIG3 influences lateral ear canal morphogenesis. Expression and sub-cellular localization of LRIG3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). Subunit: Interacts with EGFR, ERBB2 and ERBB4 (in vitro) (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4 (By similarity). Tissue Specificity: Widely expressed. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 121227 Human SwissProt: Q6UXM1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LRIG1屬于LRIGs基因家族。LRIGs是新發(fā)現(xiàn)的一類基因，在哺乳動物體內(nèi)廣泛存在，目前發(fā)現(xiàn)該家族至少包括三個成員：LRIG1、LRIG2和LRIG3，是一類結(jié)構(gòu)相似的跨膜糖蛋白，該蛋白人、鼠的同源性較高。目前在腫瘤方面的研究較多，有研究認為：LRIG1是通過下調(diào)EGFR的表達來抑制其下游重要信號傳導通路的激活而發(fā)揮抑癌作用，LRIG1在抑制腫瘤轉(zhuǎn)移中具有重要作用。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關(guān)于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
