| 產(chǎn)品編號(hào) | bs-6717R-AP |
| 英文名稱1 | Rabbit Anti-NALP2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白2抗體 |
| 別 名 | CLR19.9; FLJ20510; Leucine rich repeat and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT domain; NACHT leucine rich repeat and PYD containing 2; NACHT LRR and PYD domains containing protein 2; NALP2; NALP2_HUMAN; NBS1; NLR family pyrin domain containing 2; NLRP2; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN containing APAF1 like protein2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NACHT, LRR and PYD domains-containing protein 2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]. Function: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Subunit: Interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 8 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: Entrez Gene: 55655 Human Entrez Gene: 232827 Mouse Omim: 609364 Human SwissProt: Q9NX02 Human Unigene: 369279 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
