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Rabbit Anti-BNP/PE-Cy7 Conjugated antibody (bs-0044R-PE-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0044R-PE-Cy7
英文名稱1 Rabbit Anti-BNP/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的腦鈉素/利鈉肽抗體
別    名 BNP 32; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide brain type; Natriuretic peptide precursor B; Natriuretic peptides B; NPPB; NPPB protein; ANFB_HUMAN; Natriuretic peptides B.proBNP.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3.5kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BNP 32 (103-120aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity


Function:
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain and also in atria, but at much lower levels than ANP.

Similarity:
Belongs to the natriuretic peptide family.

Database links:

Entrez Gene: 4879 Human

Omim: 600295 Human

SwissProt: P16860 Human

Unigene: 219140 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腦鈉素主要是心臟激素,心臟作為內(nèi)分泌器官釋放腦鈉素,調(diào)解體液及電解質(zhì)內(nèi)環(huán)境的恒定性。
B型利鈉肽(鈉尿肽)(B-typenatriureticpeptide,BNP),又稱腦鈉素或腦鈉肽,因其有排鈉利尿、內(nèi)皮非依賴性的血管平滑肌作用而具有降壓、抗心肌纖維化、影響神經(jīng)內(nèi)分泌系統(tǒng)等功效。
近來發(fā)現(xiàn)BNP在各種心血管疾病,尤其是心室功能不全、急性心肌梗死(ami)、高血壓等疾病的診斷、治療及預(yù)后等方面有重要意義,已引起臨床工作者的高度重視。


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