| 產(chǎn)品編號(hào) | bs-1602R-Gold |
| 英文名稱1 | Rabbit Anti-SPA-1/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的信號(hào)感應(yīng)增殖相關(guān)蛋白1抗體 |
| 別 名 | GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 細(xì)胞周期蛋白 細(xì)胞表面分子 表觀遺傳學(xué) G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 112kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPA-1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. Tissue Specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Similarity: Contains 1 PDZ (DHR) domain. Contains 1 Rap-GAP domain. Database links: Entrez Gene: 6494 Human Entrez Gene: 20469 Mouse Omim: 602180 Human SwissProt: Q96FS4 Human SwissProt: P46062 Mouse Unigene: 530477 Human Unigene: 3072 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPA 1是重要的Rap1GTP酶激活蛋白.SPA-1參與細(xì)胞的程序性死亡，在很多惡性腫瘤的發(fā)生、發(fā)展中起到一定的作用。 |
