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Rabbit Anti-B7H4/FITC Conjugated antibody (bs-0673R-FITC)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0673R-FITC
英文名稱1 Rabbit Anti-B7H4/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的B7-H4抗體
別    名 B7-H4; B7h4; B7S1; B7x; BC032925; Immune costimulatory protein B7H4; MGC41287; PRO1291; T cell costimulatory molecule B7x; V set domain-containing T cell activation inhibitor 1; VCTN1; VTCN1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human B7H4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

Function:
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Subcellular Location:
cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected.

Tissue Specificity:
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 79679 Human

Entrez Gene: 242122 Mouse

Entrez Gene: 295322 Rat

Omim: 608162 Human

SwissProt: Q7Z7D3 Human

SwissProt: Q7TSP5 Mouse

SwissProt: Q501W4 Rat

Unigene: 546434 Human

Unigene: 137467 Mouse

Unigene: 160956 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

B7-H4(B7 Homolog 4)是B7家族中的新成員,它能通過(guò)抑制T細(xì)胞的增殖、細(xì)胞因子的產(chǎn)生和細(xì)胞周期的進(jìn)程來(lái)負(fù)性調(diào)控T細(xì)胞的免疫應(yīng)答,其大量表達(dá)B7-H4還可以促進(jìn)上皮細(xì)胞的惡性轉(zhuǎn)化,保護(hù)表皮細(xì)胞免于失巢凋亡,在腫瘤的發(fā)生,進(jìn)展和轉(zhuǎn)歸中發(fā)揮重要作用.
目前對(duì)B7-H4信號(hào)通路的進(jìn)一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應(yīng)中T細(xì)胞介導(dǎo)的免疫應(yīng)答調(diào)控提供了新的途徑,同時(shí)也為腫瘤的診斷、治療提供嶄新的前景。
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