| 產(chǎn)品編號 | bs-6070R-BF488 |
| 英文名稱1 | Rabbit Anti-phospho-LLGL1 + LLGL2(Ser650+Ser654)/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的磷酸化相似腫瘤抑制基因HUGL抗體 |
| 別 名 | LLGL1 + LLGL2 (phospho S650 + S654); LLGL1 + LLGL2 (phospho Ser650 + Ser654); p-LLGL1 + p-LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650 + Ser654); p-LLGL1/LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650/654); DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL; L2GL1_HUMAN; L2GL2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 腫瘤 細胞生物 信號轉(zhuǎn)導(dǎo) 細胞周期蛋白 細胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, k) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from mouse LLGL1 around the phosphorylation site of Ser650+Ser654 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Subunit: Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A. Subcellular Location: Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Tissue Specificity: Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at least at Ser-663 by PRKCI. Similarity: Belongs to the WD repeat L(2)GL family. Contains 14 WD repeats. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
