| 產(chǎn)品介紹 |
Neurofilament light polypeptide also called NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. Belongs to the intermediate filament family.
神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）
低分子量神經(jīng)絲蛋白,簡稱NF-L,分子量為68kDa，NF-L的聚集與神經(jīng)退行性疾病的發(fā)病機理相關(guān)，如運動神經(jīng)元的降解等。
神經(jīng)纖絲蛋白的功能是提供彈性使神經(jīng)纖維易于伸展和防止斷裂。
神經(jīng)絲是中間纖維的一種重要類型又稱神經(jīng)微絲蛋白，特異地在神經(jīng)細胞內(nèi)表達，并在軸突內(nèi)相互平行排列成束. 哺乳動物的神經(jīng)絲由3種蛋白組成：
低分子量神經(jīng)絲蛋白，簡稱NF-L；分子量為68kDa；
中分子量神經(jīng)絲蛋白，簡稱NF-M；分子量為160kDa；
高分子量神經(jīng)絲蛋白，簡稱NF
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