| 產(chǎn)品編號(hào) | V4302 |
| 英文名稱 | Human Renin |
| 中文名稱 | 人腎素/血管緊張素形成酶Ren1單克隆抗體 |
| 別 名 | Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal |
| 克 隆 號(hào) | 4C8 |
| 理論分子量 | 37kDa |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 緩 沖 液 | PBS (pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]. Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Subunit: Interacts with ATP6AP2. Subcellular Location: Secreted. Membrane. Associated to membranes via binding to ATP6AP2. DISEASE: Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. Similarity: Belongs to the peptidase A1 family. SWISS: P00797 Gene ID: 5972 Database links: Entrez Gene: 469651 Chimpanzee Entrez Gene: 5972 Human Entrez Gene: 19701 Mouse Entrez Gene: 19702 Mouse Omim: 179820 Human SwissProt: P60016 Chimpanzee SwissProt: Q6DLS0 Cynomolgus Monkey SwissProt: P00797 Human SwissProt: P00796 Mouse SwissProt: P06281 Mouse Unigene: 3210 Human Unigene: 220955 Mouse Unigene: 9831 Rat |
