| 產(chǎn)品編號 | bs-1517R-BF680 |
| 英文名稱 | Rabbit Anti-NEUROD1, BF680 conjugated antibody |
| 中文名稱 | BF680標(biāo)記的神經(jīng)細(xì)胞分化因子1抗體 |
| 別 名 | atonal; Neurod1 protein; basic helix loop helix transcription factor; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NeuroD1; neurogenic helix loop helix protein NEUROD; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; NEUROD; Neurogenic differentiation 1; Neurogenic differentiation factor 1; NIDDM; BHLHA3. |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 染色質(zhì)和核信號 神經(jīng)生物學(xué) 干細(xì)胞 新陳代謝 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 40kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEUROD1: 21-120/356 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008] Function: Acts as a transcriptional activator: mediatestranscriptional activation by binding to E box-containing promoterconsensus core sequences 5'-CANNTG-3'. Associates with the p300/CBPtranscription coactivator complex to stimulate transcription of thesecretin gene as well as the gene encoding the cyclin-dependentkinase inhibitor CDKN1A. Contributes to the regulation of severalcell differentiation pathways, like those that promote theformation of early retinal ganglion cells, inner ear sensoryneurons, granule cells forming either the cerebellum or the dentategyrus cell layer of the hippocampus, endocrine islet cells of thepancreas and enteroendocrine cells of the small intestine. Togetherwith PAX6 or SIX3, is required for the regulation of amacrine cellfate specification. Also required for dendrite morphogenesis andmaintenance in the cerebellar cortex. Associates with chromatin toenhancer regulatory elements in genes encoding key transcriptionalregulators of neurogenesis (By similarity). Subunit: Interacts (via helix-loop-helix motif domain) with EP300(via C-terminus) (By similarity). Heterodimer with TCF3/E47; theheterodimer is inhibited in presence of ID2, but not NR0B2, toE-box element. Efficient DNA-binding requires dimerization withanother bHLH protein. Interacts with RREB1. Interacts with EP300;the interaction is inhibited by NR0B2. Interacts with TCF3; theinteraction is inhibited by ID2. Subcellular Location: Cytoplasm. Nucleus. Note=Inpancreatic islet cells, shuttles to the nucleus in response toglucose stimulation. Colocalizes with NR0B2 in thenucleus. Post-translational modifications: Phosphorylated. In islet cells, phosphorylated on Ser-274upon glucose stimulation; which may be required for nuclearlocalization. In activated neurons, phosphorylated on Ser-335;which promotes dendritic growth. Phosphorylated by MAPK1;phosphorylation regulates heterodimerization and DNA-bindingactivities. Phosphorylation on Ser-266 and Ser-274 increasestransactivation on the insulin promoter in glucose-stimulatedinsulinoma cells (By similarity). DISEASE: Maturity-onset diabetes of the young 6 (MODY6)[MIM:606394]: A form of diabetes that is characterized by anautosomal dominant mode of inheritance, onset in childhood or earlyadulthood (usually before 25 years of age), a primary defect ininsulin secretion and frequent insulin-independence at thebeginning of the disease. Note=The disease is caused by mutationsaffecting the gene represented in this entry. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. SWISS: Q13562 Gene ID: 4760 Database links: Entrez Gene: 4760 Human Entrez Gene: 18012 Mouse Omim: 601724 Human SwissProt: Q13562 Human SwissProt: Q60867 Mouse Unigene: 574626 Human Unigene: 709709 Human Unigene: 4636 Mouse Unigene: 44289 Rat |
