| 產(chǎn)品編號(hào) | bs-22928R |
| 英文名稱 | Rabbit Anti-Bak antibody |
| 中文名稱 | Bcl-2同源拮抗劑抗體 |
| 別 名 | Apoptosis Regulator Bak; BAK 1; BAK; BAK like; Bak NT; BAK1; Bcl 2 homologous antagonist/killer; Bcl 2 like 7 protein; Bcl2 homologous antagonist killer; Bcl2 like 7 Protein; BCL2-antagonist/killer 1; BCL2L7; CDN 1; CDN1; Cell death inhibitor 1; MGC117255; MGC3887; NBak; Pro apoptotic protein BAK; BAK_HUMAN; BAK_MOUSE |
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Specific References (1) | bs-22928R has been referenced in 1 publications.
[IF=7.963] Jianzhao Liao. et al. Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis. Sci Total Environ. 2022 Feb;809:152188 WB ; Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Bak: 71-171/211 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008] Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Subunit: Belongs to the Bcl-2 family. Subcellular Location: Mitochondrion membrane. Tissue Specificity: Expressed in a wide variety of tissues. Similarity: Belongs to the Bcl-2 family. SWISS: O08734 Gene ID: 578 Database links:
Entrez Gene: 578 Human
Entrez Gene: 12018 Mouse
Omim: 600516 Human
SwissProt: Q16611 Human
SwissProt: Q6I9T6 Human
SwissProt: O08734 Mouse
Unigene: 485139 Human
Unigene: 2443 Mouse
Bak屬于bcl-2基因家族中的成員，具有抑制凋亡的作用。BAK基因是新發(fā)現(xiàn)的細(xì)胞凋亡促進(jìn)因子，BAK含BH1和BH2結(jié)構(gòu)域，其功能類似于BAX；拮抗BCL2、BCL-XL的抗凋亡效應(yīng)。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Molt-4 (Human) Cell Lysate at 30 ug
Lane 2: Jurkat (Human) Cell Lysate at 30 ug
Primary: Anti-Bak (bs-22928R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 25 kD
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