| 產(chǎn)品編號(hào) | bs-22374R |
| 英文名稱 | Rabbit Anti-GLUT3 antibody |
| 中文名稱 | 葡萄糖轉(zhuǎn)運(yùn)蛋白3抗體 |
| 別 名 | brain; facilitated glucose transporter member 3; Glucose Transporter GLUT3 ; FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT-3; GTR3_HUMAN; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3; Solute carrier family 2. |
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Specific References (1) | bs-22374R has been referenced in 1 publications.
[IF=6.048] Changhao Jia. et al. Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis. J NUTR BIOCHEM. 2022 May;:109038 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 54kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLUT3 : 401-496/496 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
may act as a glucose transporter in neurons; may mediate increasd glucose uptake in response to neuronal injury. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF1 induced signaling. GLUT3 is detectable in a few normal cell type spermatids in testis with active spermatogenesis, placental trophoblast membranes, and neurons in brain. GLUT3 staining is also detectable in human cancers including those of the ovary, lung, and testis. Alternative names: FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT3; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3. Function: Facilitative glucose transporter. Probably a neuronal glucose transporter. Subcellular Location: Cell membrane; Multi-pass membrane protein. Melanosome. Tissue Specificity: Highly expressed in brain. Expressed in many tissues. Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. SWISS: P11169 Gene ID: 6515 Database links: Entrez Gene: 6515 Human Entrez Gene: 20527 Mouse Omim: 138170 Human SwissProt: P11169 Human SwissProt: P32037 Mouse Unigene: 419240 Human Unigene: 395108 Mouse Unigene: 95055 Rat 交換和轉(zhuǎn)運(yùn)（Trafficking and Transport） GLUT-3屬于溶質(zhì)運(yùn)載蛋白家族成員（solute carrier family），主要功能是轉(zhuǎn)載葡萄糖進(jìn)入上皮細(xì)胞。 目前主要用于糖尿病腎病和視網(wǎng)膜病變的研究，也是腎小球系膜細(xì)胞上的主要葡萄糖轉(zhuǎn)運(yùn)體。GLUT3的功能狀態(tài)直接影響系膜細(xì)胞的糖代謝及功能變化。 近期，研究人員也用來區(qū)別一些良、惡性腫瘤的鑒別。 |
| 產(chǎn)品圖片 |
Sample:
HepG2(Human) Cell Lysate at 30 ug
SH-SY5Y(Human) Cell Lysate at 30 ug
NIH/3T3(Mouse) Cell Lysate at 30 ug
Raw264.7(Mouse) Cell Lysate at 30 ug
Cerebrum(Mouse) Lysate at 40 ug
Cerebrum(Rat) Lysate at 40 ug
Testis(Rat) Lysate at 40 ug
Primary: Anti-GLUT3 (bs-22374R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54/60 kD
Observed band size: 60 kD
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