| 產(chǎn)品編號 | bs-20422R |
| 英文名稱 | Rabbit Anti-Neogenin antibody |
| 中文名稱 | 神經(jīng)細(xì)胞粘附蛋白NGN抗體 |
| 別 名 | NGN; Neo1; Neo 1; Neogenin; NEO1_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 156kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neogenin: 1001-1100/1461 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cell surface protein that is a memberof the immunoglobulin superfamily. The encoded protein consists offour N-terminal immunoglobulin-like domains, six fibronectin typeIII domains, a transmembrane domain and a C-terminal internaldomain that shares homology with the tumor suppressor candidategene DCC. This protein may be involved in cell growth anddifferentiation and in cell-cell adhesion. Defects in this gene areassociated with cell proliferation in certain cancers. Alternatesplicing results in multiple transcript variants. [provided byRefSeq, Feb 2010]. Function: Neogenin is one of several netrin-binding proteins. Neogenin functions as an Repulsive Guidance Molecule (RGM) receptor; RGM is implicated in axonal guidance and neural tube closure. Subunit: Interacts with RGMA. Interacts with MYO10 Subcellular Location: Cell membrane; Single-pass type I membraneprotein. Tissue Specificity: Widely expressed and also in cancer celllines. Similarity: Belongs to the immunoglobulin superfamily. DCC family. Contains 6 fibronectin type-III domains. Contains 4 Ig-like C2-type (immunoglobulin-like)domains. SWISS: Q92859 Gene ID: 4756 Database links: Entrez Gene: 4756 Human Entrez Gene: 18007 Mouse Omim: 601907 Human SwissProt: Q92859 Human SwissProt: P97798 Mouse Unigene: 388613 Human Unigene: 42249 Mouse Unigene: 10667 Rat |
