| 產(chǎn)品編號 | bs-19571R |
| 英文名稱 | Rabbit Anti-OBFC2B antibody |
| 中文名稱 | 核酸結(jié)合蛋白2抗體 |
| 別 名 | 2610036N15Rik; hSSB1; LP3587; MGC125161; MGC2731; MGC30353; Nabp2; SOSB1_HUMAN; Nucleic acid binding protein 2; Oligonucleotide/oligosaccharide binding fold containing 2B; Oligonucleotide/oligosaccharide binding fold containing protein 2B; RGD1308158; Sensor of single strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single stranded DNA binding protein 1; SOSS complex subunit B1; SSB1. |
| 研究領(lǐng)域 | 細(xì)胞生物 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OBFC2B: 131-211/211 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Subunit: Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Subcellular Location: Nuclear. Localizes to nuclear foci following DNA damage. Post-translational modifications: Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells. Similarity: Belongs to the SOSS-B family. SOSS-B1 subfamily. Contains 1 OB DNA-binding domain. SWISS: Q9BQ15 Gene ID: 79035 Database links: Entrez Gene: 79035 Human Entrez Gene: 69917 Mouse Omim: 612104 Human SwissProt: Q9BQ15 Human SwissProt: Q8R2Y9 Mouse |
