| 產(chǎn)品編號 | bs-19171R |
| 英文名稱 | Rabbit Anti-MYO3A antibody |
| 中文名稱 | 肌球蛋白3A抗體 |
| 別 名 | deafness, autosomal recessive 30; DFNB30; Myo3a; MYO3A_HUMAN; Myosin IIIA; Myosin-IIIa. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 186kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MYO3A: 1081-1180/1616 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008] Function: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas. DISEASE: Deafness, autosomal recessive, 30 Similarity: In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. Contains 3 IQ domains. Contains 1 myosin head-like domain. Contains 1 protein kinase domain. SWISS: Q8NEV4 Gene ID: 53904 Database links: Entrez Gene: 53904 Human Omim: 606808 Human SwissProt: Q8NEV4 Human Unigene: 662630 Human |
