| 產(chǎn)品編號 | bs-18939R |
| 英文名稱 | Rabbit Anti-MIER3 antibody |
| 中文名稱 | 中胚層誘導(dǎo)早期反應(yīng)蛋白3抗體 |
| 別 名 | DKFZp686L09111; DKFZp781G1119; DKFZP781I1119; FLJ35954; Mesoderm induction early response 1 family member 3; Mesoderm induction early response protein 3; Mi-er3; MIER 3; MIER3; MIER3_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse,Ferret,Baboon,Rhesus monkey,Gorilla , Orangutan) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 61kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MIER3: 401-500/550 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The mesoderm induction early response (MIER) protein family (also known as the fibroblast growth factor (FGF)-regulated immediate-early protein family) comprises a group of proteins that are activated by FGF (fibroblast growth factor). This suggests that MEIR proteins may play a significant role in FGF-regulated cellular activities and in the progression of certain cancers. MIER proteins contain one SANT domain, which is involved in transcriptional activation and repression, and one ELM2 domain, which was first characterized in egl-27, a gene that is critically involved in embryonic patterning of C. elegans. MIER1, formerly known as early response 1 (ER1), was first cloned and characterized in Xenopus. Expression of MIER1 is negligible in most normal tissues, but has been found to be upregulated in breast carcinoma cell lines and tumors. MIER1 functions as a transcriptional repressor of a number of genes including Sp1 target genes, most likely through interaction with HDAC1. Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Subunit: Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Subcellular Location: Nucleus; Cytoplasm Tissue Specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. Similarity: Contains 1 ELM2 domain. Contains 1 SANT domain. SWISS: Q7Z3K6 Gene ID: 166968 Database links: Entrez Gene: 166968 Human SwissProt: Q7Z3K6 Human SwissProt: Q7Z3K6-1 Human SwissProt: Q7Z3K6-2 Human SwissProt: Q7Z3K6-3 Human SwissProt: Q7Z3K6-4 Human SwissProt: Q7Z3K6-5 Human Unigene: 657594 Human |
