| 產(chǎn)品編號 | bs-16667R |
| 英文名稱 | Rabbit Anti-INPP4A antibody |
| 中文名稱 | 聚磷酸肌醇磷酸酶4A抗體 |
| 別 名 | Type I 4-phosphatase; 107kDa; 4-bisphosphate 4-phosphatase; 9630012D15; D130048C09Rik; Inositol polyphosphate 4 phosphatase type I 107kDa; Inositol polyphosphate 4 phosphatase type I; Inositol polyphosphate 4-phosphatase type I; INP4A_HUMAN; INPP4; Inpp4a; OTTHUMP00000203138; OTTHUMP00000203139; OTTHUMP00000203141; OTTHUMP00000225217; R74740; TVAS1; Type I inositol 3 4 bisphosphate 4 phosphatase; Type I inositol 3,4 bisphosphate 4 phosphatase; Type I inositol-3. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse,Xenopus laevis) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 110kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human INPP4A: 151-250/977 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The inositol polyphosphate 4-phosphatases selectively remove the phosphate from the 4-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Both the type I and type II 4-phosphatases catalyze the hydrolysis of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Type I and type II 4-phosphatases are both alternatively spliced into two isoforms, a and b, which have been detected in human platelets, rat brain, heart, skeletal muscle and spleen; and all isoforms contain a conserved motif CKSAKDRT, which contains the active site consensus sequence C-X5-R. Both type I and II 4-phosphatases are thought to regulate the level of intracellular calcium by acting as signal terminating enzymes. Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate. Tissue Specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. Similarity: Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. SWISS: Q96PE3 Gene ID: 3631 Database links: Entrez Gene: 3631 Human Entrez Gene: 269180 Mouse Entrez Gene: 734645 Xenopus laevis Omim: 600916 Human SwissProt: Q96PE3 Human SwissProt: Q9EPW0 Mouse Unigene: 469386 Human Unigene: 5294 Mouse Unigene: 11215 Rat |
