| 產(chǎn)品編號 | bs-16221R |
| 英文名稱 | Rabbit Anti-GALNT5 antibody |
| 中文名稱 | GalNAc-T5蛋白抗體 |
| 別 名 | GALNAC T5; N acetylgalactosaminyltransferase; Polypeptide GalNAc transferase 5; polypeptide N -acetylgalactosaminyltransferase 5; pp GaNTase 5; Protein UDP acetylgalactosaminyltransferase 5; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 5; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 5. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞類型標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 106kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GALNT5: 501-600/940 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T5 (Polypeptide N-acetylgalactosaminyltransferase 5), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5, is a 940 amino acid protein that displays enzymatic activity toward EA2 peptide substrate with weaker activity toward Muc2 or Muc 1b substrates. Its N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. EXT2 directly interacts with GalNAc-T5, suggesting that these proteins may corroborate in glycosaminoglycan synthesis. Function: GALNT5 can catalyze the initial reaction in O-linked oligosaccharide biosynthesis,the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT5 has activity toward EA2 peptide substrate, but it has a weak activity toward Muc2 or Muc1b substrates. Subunit: Interacts with EXT2. Does not interact with EXT1, EXTL1 or EXTL3. Subcellular Location: Cell Membrane and Golgi Apparatus Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain. SWISS: Q7Z7M9 Gene ID: 11227 Database links: Entrez Gene: 11227 Human Entrez Gene: 241391 Mouse SwissProt: Q7Z7M9 Human SwissProt: Q8C102 Mouse |
