| 產(chǎn)品編號(hào) | bs-13846R |
| 英文名稱 | Rabbit Anti-CENTG3 antibody |
| 中文名稱 | CENTG3蛋白抗體 |
| 別 名 | AGAP-3; Agap3; AGAP3_HUMAN; ANK repeat and PH domain-containing protein 3; Arf GAP with GTPase, ANK repeat and PH domain containing protein 3; Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1; MRIP1; OTTHUMP00000213333; OTTHUMP00000213334; OTTHUMP00000213335; OTTHUMP00000213336. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CENTG3: 51-150/875 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP
OTTHUMP00000213337; domain, five PH domains, one Ras-associating domain, one Rho-GAP domain and one SAM (sterile a motif) domain. Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Subcellular Location: Cytoplasm. In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies. Tissue Specificity: Widely expressed. Similarity: Belongs to the centaurin gamma-like family. Contains 3 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain. SWISS: Q96P47 Gene ID: 116988 Database links: Entrez Gene: 116988 Human Entrez Gene: 213990 Mouse SwissProt: Q96P47 Human SwissProt: Q8VHH5 Mouse Unigene: 647075 Human Unigene: 250703 Mouse |
