| 產(chǎn)品編號 | bs-13670R |
| 英文名稱 | Rabbit Anti-TOM1L1 antibody |
| 中文名稱 | Src激活和信號分子蛋白抗體 |
| 別 名 | OK/KNS CL.3; Src activating and signaling molecule; Src activating and signaling molecule protein; Src-activating and signaling molecule protein; SRCASM; Target of Myb like protein 1; Target of Myb-like protein 1; Target of myb1 (chicken) homolog like 1; Target of myb1 (chicken) like 1; Target of myb1 like 1; TM1L1_HUMAN; TOM1 L1; TOM1 like protein 1; TOM1-like protein 1; TOM1L1; TOM1L1 protein. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Rabbit,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TOM1L1: 1-100/476 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin. Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promotes FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Subunit: Interacts with FYN, GRB2 and PIK3R1 when phosphorylated (By similarity). Interacts with LYN (By similarity). Subcellular Location: Golgi apparatus; Golgi stack. Endosome membrane. Post-translational modifications: Phosphorylated on tyrosines by FYN (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the TOM1 family. Contains 1 GAT domain. Contains 1 VHS domain. SWISS: O75674 Gene ID: 10040 Database links: Entrez Gene: 10040 Human Omim: 604701 Human SwissProt: O75674 Human Unigene: 153504 Human |
