| 產(chǎn)品編號(hào) | bs-13637R |
| 英文名稱 | Rabbit Anti-AKAP13 antibody |
| 中文名稱 | 蛋白激酶錨定蛋白13抗體 |
| 別 名 | A kinase (PRKA) anchor protein 13; A kinase anchor protein 13; A kinase anchoring protein; A-kinase anchor protein 13; AKAP 13; AKAP Lbc; AKAP-13; AKAP-Lbc; AKAP13; AKP13_HUMAN; ARHGEF13; Breast cancer nuclear receptor binding auxiliary protein; Breast cancer nuclear receptor-binding auxiliary protein; BRX; c lbc; FLJ11952; FLJ43341; Guanine nucleotide exchange factor Lbc; HA 3; HA3; Ht 31; Ht31; Human thyroid anchoring protein 31; Human thyroid-anchoring protein 31; LBC; LBC oncogene; Lymphoid blast crisis oncogene; Non oncogenic Rho GTPase specific GTP exchange factor; Non-oncogenic Rho GTPase-specific GTP exchange factor; P47; Protein kinase A anchoring protein 13; Protein kinase A-anchoring protein 13; PROTO LB; PROTO LBC. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 307kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AKAP13: 2001-2100/2813 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. Subcellular Location: Cytoplasm; Cytoplasm. Nucleus and Membrane. Tissue Specificity: Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger. SWISS: Q12802 Gene ID: 11214 Database links: Entrez Gene: 11214 Human Omim: 604686 Human SwissProt: Q12802 Human Unigene: 459211 Human Unigene: 710656 Human |
