| 產(chǎn)品編號(hào) | bs-8618R |
| 英文名稱(chēng) | Rabbit Anti-GPR7 antibody |
| 中文名稱(chēng) | G蛋白偶聯(lián)受體7抗體 |
| 別 名 | GPCR GPR7; G protein coupled receptor 7; g protein coupled receptor gpr7; GPR7; MGC129755; Neuropeptides B and W receptor 1; Neuropeptides B/W receptor 1; Neuropeptides B/W receptor type 1; NPB and NPW receptor 1; NPBWR1; opioid somatostatin like receptor 7. |
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Specific References (5) | bs-8618R has been referenced in 5 publications.
[IF=6.208] Shashank Pandey. et al. Regulation of Prepro-NeuropeptideW/B and Its Receptor in the Heart of ZDF Rats: An Animal Model of Type II DM. INT J MOL SCI. 2022 Jan;23(23):15219 WB ; Rat.
[IF=6.208] Tatiana Wojciechowicz. et al. The Effects of Neuropeptide B on Proliferation and Differentiation of Porcine White Preadipocytes into Mature Adipocytes. INT J MOL SCI. 2023 Jan;24(7):6096 WB ; Pig.
[IF=4.556] Shashank Pandey. et al. Identification of NPB, NPW and Their Receptor in the Rat Heart. Int J Mol Sci. 2020 Jan;21(21):7827 WB,IF ; Rat.
[IF=4.369] T. Wojciechowicz. et al. Neuropeptide B promotes differentiation of rodent white preadipocytes into mature adipocytes. MOL CELL ENDOCRINOL. 2023 Jan;:111850 WB ; Rat.
[IF=2.231] Tatiana Wojciechowicz. et al. Neuropeptide B promotes proliferation and differentiation of rat brown primary preadipocytes. 2021 Feb 24 WB ; Rat.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 59kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR7: 1-100/540 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively. Function: GPR7 interacts specifically with a number of opioid ligands. It is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals, and has a higher affinity for neuropeptide B. It has been reported in brain, mainly cerebellum and frontal cortex, and in the pituitary (O'Dowd et al., 1995). The mouse ortholog of GPR7 was shown by in situ hybridization to be expressed in discrete nuclei of brain, namely suprachiasmatic, arcuate, and ventromedial nuclei of hypothalamus. Subcellular Location: Cell membrane; Multipass membrane protein. SWISS: O95800 Gene ID: 10936 Database links: Entrez Gene: 428544 Chicken Entrez Gene: 101130191 Gorilla Entrez Gene: 100066961 Horse Entrez Gene: 10936 Human Entrez Gene: 237716 Mouse Entrez Gene: 100347723 Rabbit Omim: 606704 Human SwissProt: O95800 Human SwissProt: Q6X632 Mouse Unigene: 40763 Human Unigene: 338361 Mouse Unigene: 484157 Mouse |
| 產(chǎn)品圖片 |
Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-GPR7 (bs-8618R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 59 kD
Observed band size: 59 kD
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