| 產(chǎn)品編號 | bs-15094R |
| 英文名稱 | Rabbit Anti-C20orf14 antibody |
| 中文名稱 | 20號染色體開放閱讀框14抗體 |
| 別 名 | Androgen receptor N terminal domain transactivating protein 1; Chromosome 20 open reading frame 14; fc12b02; hypothetical protein LOC323855; p102 U5 small nuclear ribonucleoprotein particle binding protein; Pre mRNA processing factor 6; PRP6 homolog; PRPF 6; PRPF6; Putative mitochondrial outer membrane protein import receptor; U5 102 kDa protein; U5 snRNP associated 102 kDa protein; wu:fa05f07; wu:fc12b02; zgc:65913; PRP6_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 107kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C20orf14: 331-430/941 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. Function: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Subunit: Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones. Subcellular Location: Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles. Tissue Specificity: Widely expressed. DISEASE: Defects in PRPF6 may be the cause of retinitis pigmentosa type 60 (RP60) [MIM:613983]. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. Similarity: Contains 9 HAT repeats. SWISS: O94906 Gene ID: 24148 Database links: Entrez Gene: 24148 Human SwissProt: Q5JWF8 human |
