產(chǎn)品編號 | bs-12879R |
英文名稱 | Rabbit Anti-outer surface protein A antibody |
中文名稱 | 萊姆病螺旋體抗體 |
別 名 | outer surface protein A precursor [Borrelia burgdorferi]; OSP; OSPA_BORBU. |
Specific References (1) | bs-12879R has been referenced in 1 publications.
[IF=4.76] Lerner, Mitchell B., et al. "Large Scale Commercial Fabrication of High Quality Graphene-Based Assays for Biomolecule Detection." Sensors and Actuators B: Chemical (2016). other ;
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研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)菌及病毒 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: B burgdorferi) |
產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 83kDa |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from Borrelia burgdorferi OSP: 1-100/273 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
Borrelia burgdorferi is a spirochete and the cause of Lyme disease, a tick transmitted illness of humans and animals. B. burgdorferi may persist in humans and animals for months or years following initial infection, despite a robust humoral immune response. B. burgdorferi resembles other spirochetes in that it is a highly specialized, motile, two-membrane, spiral shaped bacteria which lives primarily as an extracellular pathogen. B. burgdorferi has an unusual genome compared with other eubacteria which includes a linear chromosome approximately one megabase in size and numerous linear and circular plasmids. SWISS: P0CL66 Gene ID: N/A 萊姆病又稱;游走性紅斑(EM)、慢性游走性紅斑(ECM)、慢性萎縮性肌皮炎(ACA)、慢性腦脊髓炎、良性淋巴細(xì)胞增生癥、慢性游走性紅斑性關(guān)節(jié)炎、少年類風(fēng)濕性關(guān)節(jié)炎、萊姆關(guān)節(jié)炎等。 萊姆病(Lyme disease)是由伯氏疏螺旋體(Bolrelia burgdorferi)引起的一種慢性自然疫源性疾病,因在1977年最先發(fā)現(xiàn)于美國康涅狄克州的萊姆鎮(zhèn)(Lyme townl而得名。 臨床表現(xiàn)初期多有典型皮膚損害——慢性游走性紅斑(ECM),同時(shí)伴有頭痛、發(fā)熱、寒戰(zhàn)、疲乏不適.局部淋巴結(jié)腫大等癥狀,后期表現(xiàn)為神經(jīng)系統(tǒng)、循環(huán)系統(tǒng)、運(yùn)動系統(tǒng)等呈間歇性、交替性出現(xiàn)的各種損害。具有分布廣、病程長、病死率較高等特點(diǎn)。如能早期診斷、早期治療??扇?。否則會出現(xiàn)嚴(yán)重并發(fā)癥。該病多發(fā)于氣候溫和的夏季,患者多在林木茂密地區(qū)野外活動時(shí)被蜱叮咬而感染,因而,幾種嗜血硬蜱是主要傳播媒介,一些脊椎動物如鼠、鹿、狗、兔等是其主要宿主。 某些脊椎動物被認(rèn)為是萊姆病的重要傳染源。不同地區(qū)傳染源的種類有所不同。在北美,白足鼠和白尾鹿被認(rèn)為是重要傳染源,一些寵物和牲畜如狗、馬、羊、牛等因與人類生活緊密相連,也引起廣泛關(guān)注。在歐洲,白尾鹿被認(rèn)為是重要傳染源,狗也與一些地區(qū)該病的流行有關(guān)。我國已從黑線姬鼠、白腹鼠、社鼠、小家鼠、嗣婧、野兔及病人體內(nèi)分離出病原體,一些家畜的感染率也很高,但作為傳染源的意義如何尚需進(jìn)一步調(diào)查。目前已分離出伯氏疏螺旋體或檢出特異性抗體的動物有自足鼠、金花鼠、負(fù)鼠、田鼠、褐家鼠、小家鼠、天山蹶鼠、小林姬鼠、白尾鹿、黑尾鹿、浣熊、狗、牛、馬、羊、兔、狼、狐貍、燕子、喜鵲等。 |