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Rabbit Anti-phospho-MYBL2 (Ser577)  antibody (bs-12553R)  
~~~促銷代碼KT202411~~~
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-12553R
英文名稱 Rabbit Anti-phospho-MYBL2 (Ser577)  antibody
中文名稱 磷酸化轉(zhuǎn)錄因子MYB相關蛋白B抗體
別    名 B MyB (phospho S577); p-B MyB (phospho S577); p-B MyB (phospho S581) (mouse); MYBB_HUMAN; Myb-related protein B; BMYB; B-Myb; B MyB; Myb-like protein 2;   
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  信號轉(zhuǎn)導  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit)
產(chǎn)品應用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 79kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MYBL2 around the phosphorylation site of Ser577: RR(p-S)PI 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in the regulation of cell survival, proliferation, and differentiation. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes.

Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Subunit:
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

Similarity:
Contains 3 HTH myb-type DNA-binding domains.

SWISS:
P10244

Gene ID:
4605

Database links:

Entrez Gene: 4605 Human

Entrez Gene: 17865 Mouse

Entrez Gene: 296344 Rat

Omim: 601415 Human

SwissProt: P10244 Human

SwissProt: P48972 Mouse

Unigene: 179718 Human

Unigene: 4594 Mouse

Unigene: 20824 Rat



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