| 產(chǎn)品編號 | bs-12337R |
| 英文名稱 | Rabbit Anti-MAEA antibody |
| 中文名稱 | 細(xì)胞增殖誘導(dǎo)蛋白5/肺癌相關(guān)蛋白10抗體 |
| 別 名 | 1110030D19Rik; Cell proliferation inducing gene 5 protein; Cell proliferation-inducing gene 5 protein; EMP; Erythroblast macrophage protein; HLC 10; HLC-10; HLC10; Human lung cancer oncogene 10 protein; Lung cancer related protein 10; lung cancer-related protein 10; Macrophage erythroblast attacher; MAEA; MAEA_HUMAN; MGC93683; PIG5; proliferation-inducing gene 5. |
| 研究領(lǐng)域 | 腫瘤 發(fā)育生物學(xué) 干細(xì)胞 細(xì)胞凋亡 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAEA: 171-250/396 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Emp is a 396 amino acid ubiquitously expressed adhesion protein. Expressed as 5 alternatively spliced isoforms, Emp contains one CTLH domain and one LisH domain. Emp can form a complex with F-actin, which is involved regulating actin distribution in erythroblasts and macrophages. Considered to assist with cell division and nuclear architecture, Emp is localized with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. Although the exact function of Emp is unknown, Emp is suggested to be involvement in erythroblast-macrophage cell attachment, terminal maturation and enucleation of erythroid cells, and inhibiting apoptosis of erythroblasts. Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. Subunit: Forms a complex with F-actin. Subcellular Location: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern. Tissue Specificity: Ubiquitous. Similarity: Contains 1 CTLH domain. Contains 1 LisH domain. SWISS: Q7L5Y9 Gene ID: 10296 Database links: Entrez Gene: 10296 Human Entrez Gene: 59003 Mouse Entrez Gene: 426024 Chicken Omim: 606801 Huma SwissProt: Q5F398 Chicken SwissProt: Q7L5Y9 Human SwissProt: Q4VC33 Mouse Unigene: 139896 Human Unigene: 281642 Mouse Unigene: 101181 Rat |
