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[KO驗(yàn)證抗體] Rabbit Anti-Neurotensin Receptor 1  antibody (bs-12002R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-12002R
英文名稱 [KO驗(yàn)證抗體] Rabbit Anti-Neurotensin Receptor 1  antibody
中文名稱 神經(jīng)降壓素受體1抗體
別    名 High affinity levocabastine insensitive neurotensin receptor; Neurotensin receptor type 1; NT R 1; NTR; NTR1; NTRH; NTRR; NTR-1; NTSR 1; NTR1_HUMAN.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 46kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NTR1/Neurotensin Receptor 1: 188-290/418 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive Neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). Neurotensin has a wide distribution in regions of the brain and in peripheral tissues where Neuro-tensin receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a five-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1b and TNFa in an ERK1/2- and Akt kinase-dependent manner.

Function:
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. NTR1 has been reported in brain, pancreas, and small intestine. ESTs have been isolated from brain and colon libraries.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

SWISS:
P30989

Gene ID:
4923

Database links:

Entrez Gene: 4923 Human

Entrez Gene: 18216 Mouse

Omim: 162651 Human

SwissProt: P30989 Human

SwissProt: O88319 Mouse

Unigene: 590869 Human

Unigene: 301712 Mouse



產(chǎn)品圖片
Sample: DU145(Human) Cell Lysate at 30 ug Primary: Anti-Neurotensin Receptor 1 (bs-12002R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46 kD Observed band size: 46 kD
Sample: LOVO(Human) Cell Lysate at 30 ug MCF-7(Human) Cell Lysate at 30 ug Primary: Anti-Neurotensin Receptor 1 (bs-12002R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46 kD Observed band size: 46 kD
Sample: Lane 1: NTSR1 KO Human 293T cell lysates Lane 2: NTSR1 KO Human 293T cell lysates Lane 3: Human 293T cell lysates Primary: Anti-Neurotensin Receptor 1 (bs-12002R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46 kDa Observed band size: 46 kDa
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