| 產(chǎn)品編號(hào) | bs-11740R |
| 英文名稱 | Rabbit Anti-EBF2 antibody |
| 中文名稱 | 早期B淋巴細(xì)胞因子2抗體 |
| 別 名 | COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN. |
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Specific References (2) | bs-11740R has been referenced in 2 publications.
[IF=14.919] Chen, Yan-Ting. et al. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance. Nat Commun. 2021 Nov;12(1):1-18 FC ; Mouse.
[IF=6.78] Andrea Estefanía Portales. et al. CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue. LIFE SCI. 2023 Jun;322:121652 FC ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 63kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EBF2: 331-400/575 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member. Function: EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Subunit: Forms either a homodimer or a heterodimer with a relatedfamily member Subcellular Location: Nuclear Similarity: Belongs to the COE family. Contains 1 IPT/TIG domain. SWISS: Q9HAK2 Gene ID: 64641 Database links: Entrez Gene: 64641 Human Entrez Gene: 13592 Mouse Entrez Gene: 373696 Xenopus laevis Entrez Gene: 394808 Xenopus tropicalis Omim: 609934 Human SwissProt: Q9HAK2 Human SwissProt: O08792 Mouse SwissProt: B7ZRI2 Xenopus laevis SwissProt: O73741 Xenopus laevis SwissProt: Q6P4K7 Xenopus tropicalis |
