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Rabbit Anti-Ghrelin Receptor  antibody (bs-11529R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-11529R
英文名稱 Rabbit Anti-Ghrelin Receptor  antibody
中文名稱 腦腸肽受體抗體
別    名 GH releasing peptide receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; GHRPR; GHS-R; GHS-R1; GHSR; GHSR_HUMAN; Growth hormone secretagogue receptor 1; Growth hormone secretagogue receptor type 1; growth hormone secretatgogue receptor.  
Specific References  (7)     |     bs-11529R has been referenced in 7 publications.
[IF=5.81] Shengyan Xi. et al. The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma. Front Pharmacol. 2021; 12: 715824  IHC ;  Mouse.  
[IF=4.994] He Zhang. et al. Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model. 2022 Mar 05  WB ;  Pig.  
[IF=4.546] Quancheng Liu. et al. FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs. Toxins. 2021 Dec;13(12):874  WB,IHC ;  Pig.  
[IF=2.784] Liu et al. Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase?B. (2018) Int.J.Mol.Med. 42:3037-3046  WB&IHC ;  Rat.  
[IF=2.407] Su MQ et al. Ghrelin fiber projections from the hypothalamic arcuate nucleus into the dorsal vagal complex and the regulation of glycolipid metabolism. Neuropeptides,2019,September 15, 101972.  IHF ;  Rat.  
[IF=2.146] Liu X et al. The role of acylated ghrelin and unacylated ghrelin in the blood and hypothalamus and their interaction with nonalcoholic fatty liver disease. Iran J Basic Med Sci . 2020 Sep;23(9):1191-1196.  WB ;  Rat.  
[IF=2.092] Brito Rosiane F. et al. Performance and serum parameters of calves (Bos taurus) subject to milk restriction associated with supplementation with 2-hydroxy-4-methylthiobutanoic acid. J Anim Sci. 2021 Apr;:  WB,IHC ;  Bovine.  
研究領域 腫瘤  神經生物學  信號轉導  生長因子和激素  細胞膜受體  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Horse)
產品應用 WB=1:500-2000,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ghrelin Receptor: 75-135/366 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the G-protein coupledreceptor family. The encoded protein may play a role in energyhomeostasis and regulation of body weight. Two identifiedtranscript variants are expressed in several tissues and areevolutionary conserved in fish and swine. One transcript, 1a,excises an intron and encodes the functional protein; this proteinis the receptor for the Ghrelin ligand and defines a neuroendocrinepathway for growth hormone release. The second transcript (1b)retains the intron and does not function as a receptor for Ghrelin;however, it may function to attenuate activity of isoform 1a.Mutations in this gene are associated with autosomal idiopathicshort stature.[provided by RefSeq, Apr 2010].

Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Pituitary and hypothalamus.

DISEASE:
Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:604271]. Short stature is defined by a subnormal rate of growth.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q6ISR8

Gene ID:
2693

Database links:

Entrez Gene: 2693 Human

Entrez Gene: 208188 Mouse

Entrez Gene: 397372 Pig

Entrez Gene: 84022 Rat

Omim: 601898 Human

SwissProt: Q6ISR8 Human

SwissProt: Q92847 Human

SwissProt: Q99P50 Mouse

SwissProt: Q95254 Pig

SwissProt: O08725 Rat

Unigene: 130212 Human

Unigene: 194721 Mouse

Unigene: 16107 Pig

Unigene: 74241 Rat



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