| 產(chǎn)品編號(hào) | bs-11399R |
| 英文名稱(chēng) | Rabbit Anti-Synaptotagmin XI antibody |
| 中文名稱(chēng) | 突觸結(jié)合蛋白11抗體 |
| 別 名 | Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; synaptotagmin XII; synaptotagmin-XII; Synaptotagmin11; Synaptotagmin12; Synaptotagmin-11; Synaptotagmin-12; SynaptotagminXI; SYT 11; SYT 12; SYT-11; SYT-12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI; DKFZp781D015; KIAA0080; MGC10881; MGC17226. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 48kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptotagmin XI: 51-100/431 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson’s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson’s disease. Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Subunit: Homodimer. Can also form heterodimers. Interacts with PARK2. Subcellular Location: Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. Post-translational modifications: Ubiquitinated and targeted to the proteasome complex for degradation. Similarity: Belongs to the synaptotagmin family. Contains 2 C2 domains. SWISS: Q9BT88 Gene ID: 23208 Database links: Entrez Gene: 23208 Human Entrez Gene: 229521 Mouse Omim: 608741 Human SwissProt: Q9BT88 Human SwissProt: Q9R0N3 Mouse Unigene: 32984 Human Unigene: 379376 Mouse Unigene: 9805 Rat |
