| 產(chǎn)品編號(hào) | bs-11372R |
| 英文名稱 | Rabbit Anti-Synaptogyrin 1 antibody |
| 中文名稱 | 神經(jīng)細(xì)胞囊泡循環(huán)蛋白1抗體 |
| 別 名 | SNG1_HUMAN;Synaptogyrin-1;Syngr1. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptogyrin 1: 51-150/580 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal isoforms (Synaptogyrin-1 and -3) and one ubiquitous isoform (Synaptogyrin-2). Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as cellugyrin, has a tyrosine phosphorylated C-terminal cytoplasmic tail and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. Synaptogyrin-4 is a 234 amino acid protein encoded by the SYNGR4 gene. Function: Involved in the regulation of short-term and long-term synaptic plasticity. Subcellular Location: Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the synaptogyrin family. Contains 1 MARVEL domain. SWISS: O43759 Gene ID: 9145 Database links: Entrez Gene: 9145 Human Entrez Gene: 20972 Mouse Entrez Gene: 100427479 Rhesus monkey Omim: 603925 Human SwissProt: O43759 Human SwissProt: O55100 Mouse SwissProt: Q5R703 Orangutan 囊泡循環(huán)蛋白,Synaptogyrin又稱p29，是均一分布于神經(jīng)系統(tǒng)的突觸囊泡蛋白，在神經(jīng)元及神經(jīng)內(nèi)分泌細(xì)胞高度表達(dá)，它是酪氨酸激酶的一個(gè)重要的囊泡相關(guān)底物。synaptogyrin為多基因家族編碼，異構(gòu)體的cDNA序列同源性為32%～46％。人的囊泡循環(huán)蛋白 cDNA有一閱讀框架，編碼234個(gè)氨基酸，分子量約25,683Da，有四個(gè)跨膜域，N端與C端朝向囊泡的胞質(zhì)面，無(wú)糖基化位點(diǎn)，蛋白分子胞漿尾的氨基酸序列與Syp有74％的同源性。 |
