| 產(chǎn)品編號(hào) | bs-11354R |
| 英文名稱 | Rabbit Anti-Piccolo antibody |
| 中文名稱 | 神經(jīng)細(xì)胞突觸蛋白PCLO抗體 |
| 別 名 | ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo (presynaptic cytomatrix protein); Piccolo, mouse, homolog of antibody Pico; Presynaptic cytomatrix protein; Protein piccolo. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 557kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Piccolo: 4951-5056/5056 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11. Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. Subunit: Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity). Subcellular Location: Cell junction, synapse. Note=Concentrated at the presynaptic side of synaptic junctions. Similarity: Contains 2 C2 domains. Contains 1 PDZ (DHR) domain. SWISS: Q9Y6V0 Gene ID: 27445 Database links: Entrez Gene: 27445 Human Entrez Gene: 26875 Mouse Omim: 604918 Human SwissProt: Q9Y6V0 Human SwissProt: Q9QYX7 Mouse Unigene: 12376 Human Unigene: 146275 Mouse Unigene: 53925 Rat |
