| 產(chǎn)品編號 | bs-11123R |
| 英文名稱 | Rabbit Anti-PCDHA10/CNRN8 antibody |
| 中文名稱 | 鈣粘蛋白相關(guān)神經(jīng)受體8抗體 |
| 別 名 | Cadherin related neuronal receptor 8; CNR 8; Cnr3; CNR8; CNRN 8; CNRN-8; CNRS 8; CNRS8; CRNR 8; Crnr3; CRNR8; Ortholog to mouse CNR8; PCDH alpha10; PCDHA 10; Pcdha14; PCDHALPHA10; Protocadherin alpha 10; rCNRv10; PCDAA_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Chicken) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 100kDa |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHA10/CNRN8: 301-400/948 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. These genes generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. PCDHA and PCDHG family members form oligomers, which also increases the diversity of PCDH proteins at the cell surface. All three gene clusters, PCDHA, PCDHB, and PCDHG show upregulated expression during brain development, and PCDHA is subsequently downregulated by myelination. Expression of all three clusters continues in the olfactory bulb, hippocampus and cerebellum until adulthood. Members of the PCDH family are potential targets in schizophrenia and bipolar disorder pathogenesis. PCDHA10 produces at least three isoforms by alternative splicing. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Similarity: Contains 6 cadherin domains. SWISS: Q9Y5I2 Gene ID: 56139 Database links: Entrez Gene: 56139 Human Entrez Gene: 12943 Mouse Omim: 606316 Human SwissProt: Q5DRF4 Chimpanzee SwissProt: Q9Y5I2 Human Unigene: 199343 Human |
| 產(chǎn)品圖片 |
Sample:
Hippocampus (Mouse) Lysate at 40 ug
Primary: Anti- PCDHA10/CNRN8 (bs-11123R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 100 kD
Observed band size: 115 kD
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