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Rabbit Anti-CMYA2/PDE4DIP  antibody (bs-9477R)  
~~~促銷代碼KT202411~~~
訂購(gòu)熱線:400-901-9800
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說(shuō)明書(shū): 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-9477R
英文名稱 Rabbit Anti-CMYA2/PDE4DIP  antibody
中文名稱 心肌病相關(guān)蛋白2抗體
別    名 Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein.  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 265kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP: 1501-1600/2365 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.

Function:
May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity).

Subunit:
Interacts with PDE4D (By similarity).

Subcellular Location:
Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus.

Tissue Specificity:
Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.

DISEASE:
Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein.

Similarity:
Contains 1 NBPF domain.

SWISS:
Q5VU43

Gene ID:
9659

Database links:

Entrez Gene: 9659 Human

Entrez Gene: 83679 Mouse

Entrez Gene: 64183 Rat

Omim: 608117 Human

SwissProt: Q5VU43 Human

SwissProt: Q80YT7 Mouse

SwissProt: Q9WUJ3 Rat

Unigene: 584841 Human

Unigene: 613082 Human

Unigene: 657490 Human

Unigene: 728768 Human

Unigene: 129840 Mouse

Unigene: 48693 Rat



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