| 產(chǎn)品編號(hào) | bs-9704R |
| 英文名稱 | Rabbit Anti-IFI35 antibody |
| 中文名稱 | 干擾素誘導(dǎo)35蛋白抗體 |
| 別 名 | IFI 35; Ifi-35; IFI35; IFP 35; IFP35; IN35; IN35_HUMAN; Interferon induced 35 kDa protein; Interferon-induced 35 kDa protein. |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞凋亡 細(xì)胞周期蛋白 細(xì)胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFI35: 101-200/286 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-? IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-?signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-? Two isoforms of IFI-35 exist due to alternative splicing events. Function: Not yet known. Subunit: Homodimer. Also interacts with B-ATF. Subcellular Location: Nucleus. Nuclear following IFN treatment. Tissue Specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells. Similarity: Belongs to the NMI family. SWISS: P80217 Gene ID: 3430 Database links: Entrez Gene: 3430 Human Omim: 600735 Human SwissProt: P80217 Human Unigene: 632258 Human |
