| 產(chǎn)品編號 | bs-9310R |
| 英文名稱 | Rabbit Anti-GPSM2 antibody |
| 中文名稱 | G蛋白信號調(diào)節(jié)蛋白2抗體 |
| 別 名 | vDFNB82; G protein signalling modulator 2 (AGS3 like C. elegans); G protein signalling modulator 2; G-protein-signaling modulator 2; Gpsm2; GPSM2_HUMAN; HGNC:29501; LGN; LGN protein; Mosaic protein LGN; Pins. |
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Specific References (1) | bs-9310R has been referenced in 1 publications.
[IF=2.96] He, Xiao-Qin, et al. "High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway." Tumor Biology 39.3 (2017): 1010428317695971. IHC-P ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 細(xì)胞分化 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Zebrafish,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 77kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPSM2: 401-500/684 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Function: lays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Subunit: Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Subcellular Location: Cytoplasm. Cytoplasm, cell cortex. Note=Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Defects in GPSM2 are the cause of Chudley-McCullough syndrome (CMCS) [MIM:604213]. An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. Psychomotor development is normal. Similarity: Belongs to the GPSM family. Contains 4 GoLoco domains. Contains 8 TPR repeats. SWISS: P81274 Gene ID: 29899 Database links: Entrez Gene: 29899 Human Entrez Gene: 76123 Mouse Omim: 609245 Human SwissProt: P81274 Human SwissProt: Q8VDU0 Mouse Unigene: 584901 Human Unigene: 658489 Human Unigene: 226941 Mouse Unigene: 144235 Rat |
